BAG4 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component:  cytosol; nucleus; plasma membrane
Molecular Function:  chaperone binding; protein binding; ubiquitin protein ligase binding
Biological Process:  cellular response to epidermal growth factor stimulus; cellular response to tumor necrosis factor; negative regulation of apoptotic process; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; negative regulation of protein targeting to mitochondrion; positive regulation of actin filament polymerization; positive regulation of cell adhesion; positive regulation of fibroblast migration; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of stress fiber assembly; protein folding; protein localization to plasma membrane; regulation of cellular response to heat; ruffle assembly; tumor necrosis factor-mediated signaling pathway
Reference #:  O95429 (UniProtKB)
Alt. Names/Synonyms: BAG family molecular chaperone regulator 4; BAG-4; BAG-family molecular chaperone regulator-4; BAG4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; Silencer of death domains; SODD
Gene Symbols: BAG4
Molecular weight: 49,594 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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