BAG4
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis |
Chromosomal Location of human Ortholog: 8p11.23 |
Cellular Component:
cytoplasm; cytosol; membrane; nucleus; plasma membrane
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Molecular Function:
adenyl-nucleotide exchange factor activity; protein binding; protein-containing complex binding; protein-folding chaperone binding; ubiquitin protein ligase binding
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Biological Process:
cellular response to epidermal growth factor stimulus; cellular response to tumor necrosis factor; negative regulation of apoptotic process; negative regulation of mRNA modification; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; negative regulation of protein targeting to mitochondrion; positive regulation of actin filament polymerization; positive regulation of cell adhesion; positive regulation of fibroblast migration; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of stress fiber assembly; protein folding; protein localization to plasma membrane; protein stabilization; ruffle assembly
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Reference #:
O95429
(UniProtKB)
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Alt. Names/Synonyms: BAG cochaperone 4; BAG family molecular chaperone regulator 4; BAG-4; BAG-family molecular chaperone regulator-4; BAG4; Bcl-2-associated athanogene 4; BCL2 associated athanogene 4; BCL2-associated athanogene 4; Silencer of death domains; SODD
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Gene Symbols: BAG4
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Molecular weight:
49,594 Da
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Basal Isoelectric point:
5.02
Predict pI for various phosphorylation states
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