REV1L Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Belongs to the DNA polymerase type-Y family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 2.7.7.-; Transferase
Chromosomal Location of human Ortholog: 2q11.2
Cellular Component:  nucleoplasm
Molecular Function:  damaged DNA binding; deoxycytidyl transferase activity; DNA-directed DNA polymerase activity; metal ion binding; protein binding
Biological Process:  DNA replication; error-free translesion synthesis; error-prone translesion synthesis; response to UV
Reference #:  Q9UBZ9 (UniProtKB)
Alt. Names/Synonyms: AIBP80; Alpha integrin-binding protein 80; DNA repair protein REV1; FLJ21523; MGC163283; MGC26225; REV1; REV1 DNA directed polymerase; REV1 homolog; REV1 homolog (S. cerevisiae); REV1, polymerase (DNA directed); REV1- like; Rev1-like terminal deoxycytidyl transferase; REV1L
Gene Symbols: REV1
Molecular weight: 138,248 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
Select Structure to View Below

REV1L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein