REV1L
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Belongs to the DNA polymerase type-Y family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA repair, damage; EC 2.7.7.-; Transferase |
Chromosomal Location of human Ortholog: 2q11.2 |
Cellular Component:
nucleoplasm
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Molecular Function:
damaged DNA binding; deoxycytidyl transferase activity; DNA-directed DNA polymerase activity; metal ion binding; protein binding
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Biological Process:
DNA replication; error-free translesion synthesis; error-prone translesion synthesis; response to UV
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Reference #:
Q9UBZ9
(UniProtKB)
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Alt. Names/Synonyms: AIBP80; Alpha integrin-binding protein 80; DNA repair protein REV1; FLJ21523; MGC163283; MGC26225; REV1; REV1 DNA directed polymerase; REV1 homolog; REV1 homolog (S. cerevisiae); REV1, polymerase (DNA directed); REV1- like; Rev1-like terminal deoxycytidyl transferase; REV1L
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Gene Symbols: REV1
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Molecular weight:
138,248 Da
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Basal Isoelectric point:
8.76
Predict pI for various phosphorylation states
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