APOBEC1 Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. Expressed exclusively in the small intestine. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  cytidine deaminase activity; cytosine deaminase activity; enzyme activator activity; mRNA 3'-UTR AU-rich region binding; protein binding; protein domain specific binding; ribonucleoprotein complex binding; zinc ion binding
Biological Process:  cellular response to insulin stimulus; cytidine deamination; cytidine to uridine editing; defense response to virus; DNA cytosine deamination; DNA demethylation; lipid metabolic process; lipoprotein biosynthetic process; lipoprotein transport; mRNA modification; mRNA processing; mRNA stabilization; negative regulation of methylation-dependent chromatin silencing; negative regulation of triglyceride metabolic process; positive regulation of catalytic activity; positive regulation of mRNA modification; regulation of cell proliferation; response to calcium ion; response to ethanol; response to gamma radiation; response to osmotic stress; response to zinc ion; RNA processing; triglyceride metabolic process
Reference #:  P41238 (UniProtKB)
Alt. Names/Synonyms: ABEC1; APOBEC-1; APOBEC1; apolipoprotein B mRNA editing enzyme catalytic subunit 1; apolipoprotein B mRNA editing enzyme complex-1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; Apolipoprotein B mRNA-editing enzyme 1; BEDP; C->U-editing enzyme APOBEC-1; CDAR1; HEPR; mRNA(cytosine(6666)) deaminase 1
Gene Symbols: APOBEC1
Molecular weight: 28,192 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
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APOBEC1

Protein Structure Not Found.

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