CHST6 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. Note: This description may include information from UniProtKB.
Protein type: EC 2.8.2.-; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component:  Golgi apparatus; Golgi membrane; integral component of membrane
Molecular Function:  N-acetylglucosamine 6-O-sulfotransferase activity
Biological Process:  carbohydrate metabolic process; keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; sulfur compound metabolic process
Disease: Macular Dystrophy, Corneal, 1
Reference #:  Q9GZX3 (UniProtKB)
Alt. Names/Synonyms: C-GlcNAc6ST; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6; Carbohydrate sulfotransferase 6; CHST6; corneal N-acetylglucosamine 6-sulfotransferase; Corneal N-acetylglucosamine-6-O-sulfotransferase; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta; GlcNAc6ST-5; Gn6st-5; GST4-beta; hCGn6ST; MCDC1; N-acetylglucosamine 6-O-sulfotransferase 5; N-acetylglucosamine 6-sulfotransferase
Gene Symbols: CHST6
Molecular weight: 44,099 Da
Basal Isoelectric point: 10.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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