RFX3 Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells. Belongs to the RFX family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component:  nuclear chromatin; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; transcription regulatory region DNA binding
Biological Process:  cell maturation; cilium assembly; cilium-dependent cell motility; endocrine pancreas development; epithelial cilium movement involved in determination of left/right asymmetry; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of type B pancreatic cell development; regulation of insulin secretion; regulation of transcription, DNA-templated; transcription, DNA-templated; type B pancreatic cell maturation
Reference #:  P48380 (UniProtKB)
Alt. Names/Synonyms: bA32F11.1; DNA binding protein RFX3; MGC87155; Regulatory factor X 3; regulatory factor X, 3 (influences HLA class II expression); RFX3; Transcription factor RFX3
Gene Symbols: RFX3
Molecular weight: 83,530 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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