ITGA3 Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Belongs to the integrin alpha chain family. Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 17q21.33
Cellular Component:  basolateral plasma membrane; cell periphery; cell surface; excitatory synapse; external side of plasma membrane; filopodium membrane; growth cone filopodium; integrin alpha3-beta1 complex; integrin complex; invadopodium membrane; perinuclear region of cytoplasm; plasma membrane; receptor complex; synaptic membrane
Molecular Function:  collagen binding; fibronectin binding; integrin binding; laminin binding; metal ion binding; protease binding; protein binding; protein domain specific binding; protein heterodimerization activity
Biological Process:  cell-matrix adhesion; dendritic spine maintenance; exploration behavior; extracellular matrix organization; heart development; integrin-mediated signaling pathway; leukocyte migration; lung development; maternal process involved in female pregnancy; memory; mesodermal cell differentiation; negative regulation of cell projection organization; negative regulation of Rho protein signal transduction; nephron development; neuron migration; positive regulation of cell-substrate adhesion; positive regulation of epithelial cell migration; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of protein localization to plasma membrane; regulation of BMP signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt signaling pathway; renal filtration; response to drug; response to gonadotropin; skin development
Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Reference #:  P26006 (UniProtKB)
Alt. Names/Synonyms: alpha 3 subunit of VLA-3 receptor; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49C; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3; ILNEB; integrin alpha 3; Integrin alpha-3; Integrin alpha-3 heavy chain; Integrin alpha-3 light chain; integrin subunit alpha 3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITA3; ITGA3; MSK18; testicular tissue protein Li 96; testicular tissue protein Li 98; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a
Gene Symbols: ITGA3
Molecular weight: 116,612 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein