PKCB iso2 an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC; Kinase, protein; Motility/polarity/chemotaxis; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p12.2-p12.1
Cellular Component:  calyx of Held; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; presynaptic cytosol
Molecular Function:  androgen receptor binding; ATP binding; calcium channel regulator activity; chromatin binding; histone binding; histone kinase activity (H3-T6 specific); nuclear receptor transcription coactivator activity; protein binding; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity; zinc ion binding
Biological Process:  adaptive immune response; apoptotic process; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; histone H3-T6 phosphorylation; lipoprotein transport; mitotic nuclear envelope disassembly; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; platelet activation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of nucleic acid-templated transcription; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; protein phosphorylation; regulation of myeloid cell differentiation; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction
Reference #:  P05771-2 (UniProtKB)
Alt. Names/Synonyms: KPCB; MGC41878; PKC beta 2; PKC beta II; PKC beta2; PKC-B; PKC-beta; PKC-beta II; PKCB; PRKCB; PRKCB1; PRKCB2; protein kinase C beta 1; Protein kinase C beta type; protein kinase C, beta; protein kinase C, beta 1 polypeptide
Gene Symbols: PRKCB
Molecular weight: 77,012 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKCB iso2

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Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein