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PNRC2
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. Belongs to the PNRC family. PNRC2 subfamily. Expressed in heart, lung, muscle and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription regulation |
| Chromosomal Location of human Ortholog: 1p36.11 |
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Cellular Component:
cytosol; Golgi apparatus; nucleoplasm; nucleus; P-body
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Molecular Function:
protein binding
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Biological Process:
deadenylation-independent decapping of nuclear-transcribed mRNA; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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Reference #:
Q9NPJ4
(UniProtKB)
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Alt. Names/Synonyms: FLJ20312; MGC99541; PNRC2; proline rich nuclear receptor coactivator 2; Proline-rich nuclear receptor coactivator 2
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Gene Symbols: PNRC2
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Molecular weight:
15,591 Da
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Basal Isoelectric point:
10.4
Predict pI for various phosphorylation states
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