GRHPR Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Ubiquitous. Most abundantly expressed in the liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC; EC; Oxidoreductase
Chromosomal Location of mouse Ortholog: 4|4 B1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  carboxylic acid binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; NAD binding; NADP binding; NADPH binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein homodimerization activity
Biological Process:  dicarboxylic acid metabolic process; excretion; glyoxylate metabolic process; oxidation-reduction process; protein complex oligomerization
Reference #:  Q91Z53 (UniProtKB)
Alt. Names/Synonyms: 1110059D05Rik; 6430629L09Rik; Glxr; Glyoxylate reductase/hydroxypyruvate reductase; Grhpr; OTTMUSP00000007553
Gene Symbols: Grhpr
Molecular weight: 35,329 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene