RAP1B GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Belongs to the small GTPase superfamily. Ras family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras
Chromosomal Location of Human Ortholog: 7q22
Cellular Component:  cell-cell junction; cytosol; exocytic vesicle; lipid droplet; plasma membrane
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein-containing complex binding
Biological Process:  cell proliferation; cellular response to cAMP; cellular response to drug; cellular response to gonadotropin-releasing hormone; cellular response to organic cyclic compound; establishment of endothelial barrier; negative regulation of calcium ion-dependent exocytosis; negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; Rap protein signal transduction; regulation of cell junction assembly; regulation of establishment of cell polarity; response to carbohydrate; small GTPase mediated signal transduction
Reference #:  Q62636 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein smg p21B; MGC93206; Rap1b; RAP1B, member of RAS oncogene family; RAS related protein 1b; Ras-related protein Rap-1b
Gene Symbols: Rap1b
Molecular weight: 20,798 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene