Abl iso2 an ubiquitous and highly conserved, proto-oncogenic non-receptor tyrosine kinase that plays a role in many key processes including cell growth and survival, actin remodeling, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Negatively regulated by its SH3 domain. Deletion of the SH3 domain turns ABL1 into an oncogene. The Philadelphia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Is inhibited by active-site binding small molecules such as imatinib (Gleevec), Dasatinib, Nilotinib, Bosutinib, Ponatinib, and Bafetinib. Compounds such as GNF-2 that bind the myristate-binding pocket of Abl allosterically inhibit Abl kinase activity. Modulates the endocytosis of activated B-cell receptor complexes. Regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Mitochondrial dysfunction and cell death in response to oxidative stress. Translocates to the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Regulates T-cell differentiation in a TBX21-dependent manner. Two alternatively-spliced human isoforms have been described: one that is N-terminally myristoylated and the other not due to an alternative splicing of the first exon. Note: This description may include information from UniProtKB.
Protein type: Abl family; EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 9q34.12
Cellular Component:  actin cytoskeleton; cell leading edge; cytoplasm; cytosol; dendrite; mitochondrion; neuronal cell body; nuclear body; nuclear membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; protein-containing complex
Molecular Function:  actin filament binding; actin monomer binding; ATP binding; bubble DNA binding; DNA binding; ephrin receptor binding; four-way junction DNA binding; kinase activity; magnesium ion binding; manganese ion binding; mitogen-activated protein kinase binding; neuropilin binding; nicotinate-nucleotide adenylyltransferase activity; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding; proline-rich region binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase C binding; protein tyrosine kinase activity; sequence-specific double-stranded DNA binding; SH2 domain binding; SH3 domain binding; syntaxin binding; transcription coactivator activity
Biological Process:  actin cytoskeleton organization; actin filament branching; activated T cell proliferation; activation of protein kinase C activity; alpha-beta T cell differentiation; autophagy; B cell proliferation involved in immune response; B cell receptor signaling pathway; B-1 B cell homeostasis; Bergmann glial cell differentiation; cardiovascular system development; cell cycle arrest; cellular protein modification process; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cellular response to oxidative stress; cerebellum morphogenesis; collateral sprouting; DNA conformation change; DNA damage induced protein phosphorylation; endocytosis; endothelial cell migration; epidermal growth factor receptor signaling pathway; establishment of protein localization; Fc-gamma receptor signaling pathway involved in phagocytosis; integrin-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; microspike assembly; mismatch repair; mitochondrial depolarization; mitotic cell cycle; negative regulation of BMP signaling pathway; negative regulation of cell-cell adhesion; negative regulation of cellular senescence; negative regulation of endothelial cell apoptotic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of long-term synaptic potentiation; negative regulation of mitotic cell cycle; negative regulation of phospholipase C activity; negative regulation of protein serine/threonine kinase activity; negative regulation of ubiquitin-protein transferase activity; neural tube closure; neuroepithelial cell differentiation; neuromuscular process controlling balance; neuropilin signaling pathway; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor-beta signaling pathway; positive regulation blood vessel branching; positive regulation of actin cytoskeleton reorganization; positive regulation of actin filament binding; positive regulation of apoptotic process; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-gamma secretion; positive regulation of interleukin-2 secretion; positive regulation of microtubule binding; positive regulation of mitotic cell cycle; positive regulation of muscle cell differentiation; positive regulation of neuron death; positive regulation of osteoblast proliferation; positive regulation of oxidoreductase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway, planar cell polarity pathway; post-embryonic development; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of actin cytoskeleton reorganization; regulation of autophagy; regulation of axon extension; regulation of Cdc42 protein signal transduction; regulation of cell adhesion; regulation of cell motility; regulation of endocytosis; regulation of extracellular matrix organization; regulation of hematopoietic stem cell differentiation; regulation of microtubule polymerization; regulation of modification of synaptic structure; regulation of response to DNA damage stimulus; regulation of T cell differentiation; regulation of transcription, DNA-templated; response to oxidative stress; signal transduction in response to DNA damage; spleen development; substrate adhesion-dependent cell spreading; T cell receptor signaling pathway; thymus development; transitional one stage B cell differentiation
Disease: Congenital Heart Defects And Skeletal Malformations Syndrome; Leukemia, Chronic Myeloid
Reference #:  P00519-2 (UniProtKB)
Alt. Names/Synonyms: Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; ABL; Abl iso2; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; BCR-ABL; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; CHDSKM; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; truncated ABL protooncogene 1 nonreceptor tyrosine kinase; Tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1
Gene Symbols: ABL1
Molecular weight: 124,955 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Abl iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene