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DNAH5
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Belongs to the dynein heavy chain family. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of human Ortholog: 5p15.2 |
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Cellular Component:
9+0 motile cilium; 9+2 motile cilium; axoneme; cytoplasm; extracellular region; microtubule; motile cilium; outer dynein arm
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Molecular Function:
ATP binding; dynein intermediate chain binding; dynein light intermediate chain binding; minus-end-directed microtubule motor activity
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Biological Process:
cilium assembly; cilium movement; cilium movement involved in cell motility; determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; flagellated sperm motility; heart development; lateral ventricle development; outer dynein arm assembly
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Disease: Ciliary Dyskinesia, Primary, 3
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Reference #:
Q8TE73
(UniProtKB)
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Alt. Names/Synonyms: Axonemal beta dynein heavy chain 5; CILD3; Ciliary dynein heavy chain 5; DNAH5; DNAHC5; DYH5; Dynein axonemal heavy chain 5; Dynein heavy chain 5, axonemal; dynein, axonemal, heavy chain 5; dynein, axonemal, heavy polypeptide 5; FLJ46759; HL1; KIAA1603; KTGNR; PCD
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Gene Symbols: DNAH5
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Molecular weight:
529,021 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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