POLR2I
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; RNA processing; Transcription initiation complex; Transferase |
Chromosomal Location of mouse Ortholog: 7|7 B1 |
Cellular Component:
DNA-directed RNA polymerase complex; nucleoplasm; nucleus; RNA polymerase II, core complex
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Molecular Function:
DNA-directed 5'-3' RNA polymerase activity; metal ion binding; nucleic acid binding; zinc ion binding
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Biological Process:
DNA-templated transcription; maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II; transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
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Reference #:
P60898
(UniProtKB)
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Alt. Names/Synonyms: 2810002B19Rik; DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II subunit RPB9; MGC73656; OTTMUSP00000027176; Polr2i; polymerase (RNA) II (DNA directed) polypeptide I; RNA polymerase II 14.5 kDa subunit; RNA polymerase II subunit B9; RPB14.5; RPB9
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Gene Symbols: Polr2i
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Molecular weight:
14,523 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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