FZR1 Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Belongs to the WD repeat CDC20/Fizzy family. Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytosol; nuclear membrane; nucleoplasm
Molecular Function:  anaphase-promoting complex binding; protein binding; ubiquitin-protein transferase activator activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; DNA repair; lens fiber cell differentiation; negative regulation of cell aging; positive regulation of cell proliferation; positive regulation of protein catabolic process; positive regulation of ubiquitin protein ligase activity; protein K11-linked ubiquitination; regulation of meiotic nuclear division; regulation of mitotic cell cycle phase transition; signal transduction involved in G2 DNA damage checkpoint; ubiquitin-dependent protein catabolic process
Reference #:  Q9UM11 (UniProtKB)
Alt. Names/Synonyms: CDC20 homolog 1; CDC20-like 1b; CDC20-like protein 1; CDC20C; CDH1; Cdh1/Hct1 homolog; fizzy and cell division cycle 20 related 1; Fizzy-related protein homolog; fizzy/cell division cycle 20 related 1; fizzy/cell division cycle 20 related 1 (Drosophila); FYR; FZR; FZR1; FZR2; HCDH; hCDH1; KIAA1242
Gene Symbols: FZR1
Molecular weight: 55,179 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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