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HPCA
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. Belongs to the recoverin family. Brain specific. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of rat Ortholog: 5q36 |
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Cellular Component:
axon; cytoplasm; cytosol; dendrite cytoplasm; dendrite membrane; dendritic spine head; glutamatergic synapse; membrane; neuronal cell body membrane; perikaryon; postsynapse
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Molecular Function:
actin binding; calcium ion binding; identical protein binding; kinase binding; protein binding
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Biological Process:
activation of phospholipase D activity; calcium-mediated signaling; cellular response to calcium ion; cellular response to electrical stimulus; cellular response to L-glutamate; inner ear development; negative regulation of guanylate cyclase activity; positive regulation of adenylate cyclase activity; positive regulation of phospholipase activity; positive regulation of protein targeting to membrane; regulation of postsynaptic neurotransmitter receptor internalization; regulation of voltage-gated calcium channel activity; response to Aroclor 1254; response to ketamine; response to L-glutamate; response to organic cyclic compound; retina development in camera-type eye
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Reference #:
P84076
(UniProtKB)
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Alt. Names/Synonyms: calcium-binding protein; hippocalcin; Hpca; MGC105450; Neuron-specific calcium-binding protein hippocalcin; P23K
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Gene Symbols: Hpca
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Molecular weight:
22,427 Da
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Basal Isoelectric point:
4.87
Predict pI for various phosphorylation states
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