SEPT5 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Expressed at high levels in the CNS, as well as in heart and platelets (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle
Chromosomal Location of rat Ortholog: 11q23
Cellular Component:  axon terminus; calyx of Held; cell cortex; cell division site; cleavage furrow; cytoskeleton; microtubule cytoskeleton; plasma membrane; presynapse; septin complex; septin ring; stress fiber; synapse; synaptic vesicle; terminal bouton
Molecular Function:  GDP binding; GTP binding; GTPase activity; identical protein binding; molecular adaptor activity; phosphatidylinositol binding; protein binding; protein homodimerization activity; syntaxin binding
Biological Process:  adult behavior; cytoskeleton-dependent cytokinesis; positive regulation of exocytosis; regulation of exocytosis; regulation of synaptic vesicle docking; social behavior
Reference #:  Q9JJM9 (UniProtKB)
Alt. Names/Synonyms: CDCrel-1; CDCrel-1A; Cell division control-related protein 1; peanut-like 1; Peanut-like protein 1; Pnutl1; Sept5; septin 5; Septin-5; Septin5
Gene Symbols: Septin5
Molecular weight: 42,852 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene