SERPINB12 Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. Belongs to the serpin family. Ov-serpin subfamily. Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of human Ortholog: 18q21.33
Cellular Component:  cytoplasm; ficolin-1-rich granule membrane; plasma membrane
Molecular Function:  enzyme binding; serine-type endopeptidase inhibitor activity
Biological Process:  hematopoietic progenitor cell differentiation; negative regulation of protein catabolic process; neutrophil degranulation
Reference #:  Q96P63 (UniProtKB)
Alt. Names/Synonyms: MGC119247; MGC119248; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12; Serpin B12; serpin family B member 12; serpin peptidase inhibitor, clade B (ovalbumin), member 12; SERPINB12; SPB12; YUKOPIN
Gene Symbols: SERPINB12
Molecular weight: 46,276 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB