SP1 Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112. Belongs to the Sp1 C2H2-type zinc-finger protein family. Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cytoplasm; nuclear chromatin; nucleoplasm; nucleus; protein-DNA complex; transcriptional repressor complex
Molecular Function:  bHLH transcription factor binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; histone acetyltransferase binding; histone deacetylase binding; HMG box domain binding; metal ion binding; protein binding; protein C-terminus binding; protein homodimerization activity; proximal promoter sequence-specific DNA binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  cellular response to insulin stimulus; positive regulation by host of viral transcription; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of gene expression; positive regulation of hydrogen sulfide biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial cell proliferation; regulation of cholesterol biosynthetic process; regulation of phenotypic switching by transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to hydroperoxide; rhythmic process; snRNA transcription by RNA polymerase II; viral process
Reference #:  P08047 (UniProtKB)
Alt. Names/Synonyms: SP1; Sp1 transcription factor; specificity protein 1; Transcription factor Sp1; TSFP1
Gene Symbols: SP1
Molecular weight: 80,693 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SP1

Protein Structure Not Found.


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