PCSK2 Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. Belongs to the peptidase S8 family. Furin subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of human Ortholog: 20p12.1
Cellular Component:  dendrite; extracellular space; intracellular membrane-bounded organelle; membrane; neuron projection; nucleoplasm; perikaryon; secretory granule; transport vesicle
Molecular Function:  protein binding; serine-type endopeptidase activity
Biological Process:  enkephalin processing; insulin processing; islet amyloid polypeptide processing; nervous system development; peptide hormone processing; protein autoprocessing; protein processing; proteolysis
Reference #:  P16519 (UniProtKB)
Alt. Names/Synonyms: KEX2-like endoprotease 2; NEC 2; NEC-2; NEC2; Neuroendocrine convertase 2; PC2; PCSK2; Prohormone convertase 2; Proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; SPC2; subtilisin-like prohormone convertases
Gene Symbols: PCSK2
Molecular weight: 70,565 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein