F9 Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: X A6|X 33.5 cM
Cellular Component:  extracellular region; extracellular space
Molecular Function:  calcium ion binding; endopeptidase activity; hydrolase activity; metal ion binding; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  blood coagulation; hemostasis; proteolysis; zymogen activation
Reference #:  P16294 (UniProtKB)
Alt. Names/Synonyms: AW111646; Cf-9; Cf9; Christmas factor; Coagulation factor IX; Coagulation factor IXa heavy chain; Coagulation factor IXa light chain; F9; FA9
Gene Symbols: F9
Molecular weight: 52,978 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene