NRXN1 Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. Belongs to the neurexin family. Brain. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component:  cell junction; cell surface; endoplasmic reticulum; GABA-ergic synapse; glutamatergic synapse; integral component of plasma membrane; integral component of presynaptic active zone membrane; neuronal cell body; nuclear membrane; nucleolus; plasma membrane; presynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse; vesicle
Molecular Function:  acetylcholine receptor binding; calcium channel regulator activity; calcium ion binding; cell adhesion molecule binding; neuroligin family protein binding; protein binding; signaling receptor activity
Biological Process:  adult behavior; axon guidance; chemical synaptic transmission; gephyrin clustering involved in postsynaptic density assembly; learning; neuroligin clustering involved in postsynaptic membrane assembly; neuromuscular process controlling balance; neuron cell-cell adhesion; neurotransmitter secretion; positive regulation of excitatory postsynaptic potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; regulation of grooming behavior; regulation of postsynaptic density assembly; regulation of presynapse assembly; regulation of synaptic vesicle cycle; social behavior; synapse assembly; synaptic membrane adhesion; trans-synaptic signaling by endocannabinoid; vocal learning; vocalization behavior
Disease: Chromosome 2p16.3 Deletion Syndrome; Pitt-hopkins-like Syndrome 2
Reference #:  Q9ULB1 (UniProtKB)
Alt. Names/Synonyms: DKFZp313P2036; FLJ35941; Hs.22998; KIAA0578; neurexin 1; neurexin I; Neurexin I-alpha; neurexin I-beta; Neurexin-1; Neurexin-1-alpha; neurexin-1-beta; NRX1A; NRXN1; PTHSL2; SCZD17
Gene Symbols: NRXN1
Molecular weight: 161,883 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein