LAX1 Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cytosol; Golgi apparatus; integral component of membrane; plasma membrane
Molecular Function:  protein binding; protein kinase binding; SH2 domain binding
Biological Process:  adaptive immune response; antigen receptor-mediated signaling pathway; B cell activation; immune response; immunoglobulin secretion; inactivation of MAPK activity; intracellular signal transduction; negative regulation of T cell activation
Reference #:  Q8IWV1 (UniProtKB)
Alt. Names/Synonyms: FLJ20340; LAT-like membrane associated protein; LAX; LAX1; Linker for activation of X cells; Lymphocyte transmembrane adapter 1; lymphocyte transmembrane adaptor 1; Membrane-associated adapter protein LAX
Gene Symbols: LAX1
Molecular weight: 44,085 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein