THBS1 Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. Belongs to the thrombospondin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 15q14
Cellular Component:  cell surface; collagen-containing extracellular matrix; endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule; platelet alpha granule lumen; sarcoplasmic reticulum; secretory granule
Molecular Function:  calcium ion binding; collagen V binding; extracellular matrix structural constituent; fibrinogen binding; fibroblast growth factor binding; fibronectin binding; heparin binding; identical protein binding; integrin binding; laminin binding; low-density lipoprotein particle binding; phosphatidylserine binding; protein binding; proteoglycan binding; transforming growth factor beta binding
Biological Process:  activation of MAPK activity; behavioral response to pain; cell adhesion; cell cycle arrest; cell migration; cellular response to growth factor stimulus; cellular response to heat; cellular response to tumor necrosis factor; chronic inflammatory response; engulfment of apoptotic cell; extracellular matrix organization; immune response; inflammatory response; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell-matrix adhesion; negative regulation of cGMP-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion assembly; negative regulation of interleukin-12 production; negative regulation of nitric oxide mediated signal transduction; negative regulation of plasma membrane long-chain fatty acid transport; negative regulation of plasminogen activation; negative regulation of sprouting angiogenesis; peptide cross-linking; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of endothelial cell apoptotic process; positive regulation of endothelial cell migration; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fibroblast migration; positive regulation of macrophage activation; positive regulation of macrophage chemotaxis; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta1 production; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; regulation of megakaryocyte differentiation; response to calcium ion; response to drug; response to endoplasmic reticulum stress; response to glucose; response to hypoxia; response to magnesium ion; response to mechanical stimulus; response to progesterone; response to testosterone; response to unfolded protein; sprouting angiogenesis
Reference #:  P07996 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein G; THBS; THBS-1; THBS1; thrombospondin 1; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; TSP; TSP-1; TSP1
Gene Symbols: THBS1
Molecular weight: 129,383 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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THBS1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB