GALNT13 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Specifically expressed in neuronal cells. Expressed in fetal brain, whole adult brain, cerebral cortex and cerebellum. Not expressed in other tissues tested. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 2q23.3-q24.1
Cellular Component:  Golgi membrane; integral component of membrane
Molecular Function:  carbohydrate binding; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity
Biological Process:  O-glycan processing; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine
Reference #:  Q8IUC8 (UniProtKB)
Alt. Names/Synonyms: FLJ16031; FLJ41157; GalNAc transferase 13; GalNAc-T13; GALNT13; GLT13; H_NH0187G20.1; KIAA1918; MGC119459; MGC119461; Polypeptide GalNAc transferase 13; Polypeptide N-acetylgalactosaminyltransferase 13; pp-GaNTase 13; Protein-UDP acetylgalactosaminyltransferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13); WUGSC:H_NH0187G20.1
Gene Symbols: GALNT13
Molecular weight: 64,051 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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