GALC
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. Belongs to the glycosyl hydrolase 59 family. Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.2.1.46; Hydrolase; Lipid Metabolism - sphingolipid |
Chromosomal Location of human Ortholog: 14q31.3 |
Cellular Component:
lysosomal lumen; lysosome
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Molecular Function:
galactosylceramidase activity
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Biological Process:
galactosylceramide catabolic process; glycosphingolipid metabolic process; myelination
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Disease: Krabbe Disease
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Reference #:
P54803
(UniProtKB)
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Alt. Names/Synonyms: Galactocerebrosidase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase; galactosylceraminidase; GALC; GALCERase; testis tissue sperm-binding protein Li 88E; testis tissue sperm-binding protein Li 89A
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Gene Symbols: GALC
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Molecular weight:
77,063 Da
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Basal Isoelectric point:
6.17
Predict pI for various phosphorylation states
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