GABRD GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1p36.33
Cellular Component:  cell junction; chloride channel complex; GABA-ergic synapse; glutamatergic synapse; integral component of postsynaptic membrane
Molecular Function:  chloride channel activity; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chloride transmembrane transport; regulation of postsynaptic membrane potential
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 10
Reference #:  O14764 (UniProtKB)
Alt. Names/Synonyms: EIG10; EJM7; GABA(A) receptor subunit delta; GABA(A) receptor, delta; GABA-A receptor, delta polypeptide; GABRD; gamma-aminobutyric acid (GABA) A receptor, delta; Gamma-aminobutyric acid receptor subunit delta; gamma-aminobutyric acid type A receptor delta subunit; gamma-aminobutyric acid type A receptor subunit delta; GBRD; GEFSP5; MGC45284
Gene Symbols: GABRD
Molecular weight: 50,708 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene