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GABRD
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 1p36.33 |
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Cellular Component:
cell junction; chloride channel complex; GABA-ergic synapse; glutamatergic synapse; integral component of postsynaptic membrane
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Molecular Function:
chloride channel activity; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
chloride transmembrane transport; regulation of postsynaptic membrane potential
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Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 10
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Reference #:
O14764
(UniProtKB)
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Alt. Names/Synonyms: EIG10; EJM7; GABA(A) receptor subunit delta; GABA(A) receptor, delta; GABA-A receptor, delta polypeptide; GABRD; gamma-aminobutyric acid (GABA) A receptor, delta; Gamma-aminobutyric acid receptor subunit delta; gamma-aminobutyric acid type A receptor delta subunit; gamma-aminobutyric acid type A receptor subunit delta; GBRD; GEFSP5; MGC45284
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Gene Symbols: GABRD
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Molecular weight:
50,708 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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