IRE2 Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; IRE family; Kinase, protein; Membrane protein, integral; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component:  integral component of membrane; IRE1-TRAF2-ASK1 complex
Molecular Function:  ATP binding; endonuclease activity; magnesium ion binding; protein serine/threonine kinase activity
Biological Process:  activation of JUN kinase activity; apoptotic chromosome condensation; cell cycle arrest; mRNA processing; negative regulation of transcription, DNA-templated; protein phosphorylation; response to endoplasmic reticulum stress; RNA phosphodiester bond hydrolysis, endonucleolytic; rRNA catabolic process
Reference #:  Q76MJ5 (UniProtKB)
Alt. Names/Synonyms: endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 2; ERN2; hIRE2p; inositol-requiring 1 beta; Inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1-beta; IRE1b; IRE2; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE2
Gene Symbols: ERN2
Molecular weight: 102,480 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein