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ZRSR2
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Widely expressed. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing |
| Chromosomal Location of human Ortholog: Xp22.2 |
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Cellular Component:
nucleoplasm; spliceosomal complex; U12-type spliceosomal complex; U2AF complex
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Molecular Function:
identical protein binding; metal ion binding; pre-mRNA 3'-splice site binding; protein binding
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Biological Process:
mRNA splicing, via spliceosome; RNA splicing; spliceosomal complex assembly
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Reference #:
Q15696
(UniProtKB)
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Alt. Names/Synonyms: CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; MGC142014; MGC142040; Renal carcinoma antigen NY-REN-20; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2AF1-RS2; U2AF1L2; U2AF1RS2; U2AF35-related protein; U2AFM; URP; ZC3H22; zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2; zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2; zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2; ZRSR2
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Gene Symbols: ZRSR2
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Molecular weight:
58,045 Da
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Basal Isoelectric point:
9.75
Predict pI for various phosphorylation states
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