NMDAR1 a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p13
Cellular Component:  basolateral plasma membrane; cell junction; cell surface; cytoplasm; dendrite; dendrite membrane; dendritic branch; dendritic spine; endoplasmic reticulum; excitatory synapse; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of plasma membrane; integral component of postsynaptic density membrane; integral component of presynaptic membrane; membrane; neuronal cell body; NMDA selective glutamate receptor complex; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synapse; synaptic cleft; synaptic membrane; synaptic vesicle; terminal bouton
Molecular Function:  amyloid-beta binding; calcium channel activity; calcium ion binding; calmodulin binding; cation channel activity; enzyme binding; glutamate binding; glutamate receptor binding; glutamate-gated calcium ion channel activity; glycine binding; ionotropic glutamate receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; neurotransmitter binding; NMDA glutamate receptor activity; phosphatase binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein-containing complex binding; signaling receptor binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated cation channel activity
Biological Process:  adult locomotory behavior; associative learning; calcium ion homeostasis; calcium ion transmembrane import into cytosol; calcium ion transport; calcium-mediated signaling; cation transmembrane transport; cation transport; cellular calcium ion homeostasis; cellular response to manganese ion; cerebral cortex development; conditioned taste aversion; excitatory postsynaptic potential; ionotropic glutamate receptor signaling pathway; learning; learning or memory; long-term memory; male mating behavior; memory; negative regulation of neuron apoptotic process; neuromuscular process; olfactory learning; pons maturation; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity; positive regulation of dendritic spine maintenance; positive regulation of excitatory postsynaptic potential; positive regulation of reactive oxygen species biosynthetic process; positive regulation of Schwann cell migration; positive regulation of transcription by RNA polymerase II; prepulse inhibition; propylene metabolic process; protein heterotetramerization; protein localization to postsynaptic membrane; protein tetramerization; regulation of axonogenesis; regulation of cell communication; regulation of dendrite morphogenesis; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of neuron apoptotic process; regulation of neuronal synaptic plasticity; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential; regulation of respiratory gaseous exchange; regulation of synapse assembly; regulation of synaptic plasticity; respiratory gaseous exchange; response to amine; response to amphetamine; response to calcium ion; response to ethanol; response to fungicide; response to glycine; response to morphine; response to organic cyclic compound; rhythmic process; sensory perception of pain; social behavior; startle response; suckling behavior; synaptic transmission, glutamatergic; visual learning
Reference #:  P35439 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; Grin1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; Nmdar1; NMDZ1; NR1
Gene Symbols: Grin1
Molecular weight: 105,509 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene