NMDAR1 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 3p13
Cellular Component:  basolateral plasma membrane; cell surface; cytoplasm; dendrite; dendrite membrane; dendritic branch; dendritic spine; endoplasmic reticulum; endoplasmic reticulum membrane; excitatory synapse; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; neuron projection; neuronal cell body; NMDA selective glutamate receptor complex; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic active zone membrane; presynaptic membrane; synapse; synaptic cleft; synaptic membrane; synaptic vesicle; synaptic vesicle membrane; terminal bouton
Molecular Function:  amyloid-beta binding; calcium channel activity; calcium ion binding; calmodulin binding; enzyme binding; glutamate binding; glutamate receptor binding; glutamate-gated calcium ion channel activity; glycine binding; ionotropic glutamate receptor activity; ionotropic glutamate receptor binding; ligand-gated monoatomic ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; monoatomic cation channel activity; neurotransmitter binding; NMDA glutamate receptor activity; phosphatase binding; protein binding; protein-containing complex binding; signaling receptor activity; signaling receptor binding; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic cation channel activity
Biological Process:  adult locomotory behavior; associative learning; calcium ion homeostasis; calcium ion transmembrane import into cytosol; calcium ion transport; calcium-mediated signaling; cellular response to amyloid-beta; cellular response to manganese ion; cerebral cortex development; chemical synaptic transmission; conditioned taste aversion; excitatory postsynaptic potential; intracellular calcium ion homeostasis; ionotropic glutamate receptor signaling pathway; learning; learning or memory; long-term memory; male mating behavior; memory; monoatomic cation transmembrane transport; monoatomic cation transport; monoatomic ion transmembrane transport; negative regulation of neuron apoptotic process; neuromuscular process; neuron cellular homeostasis; olfactory learning; pons maturation; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of cysteine-type endopeptidase activity; positive regulation of dendritic spine maintenance; positive regulation of excitatory postsynaptic potential; positive regulation of reactive oxygen species biosynthetic process; positive regulation of Schwann cell migration; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription by RNA polymerase II; prepulse inhibition; propylene metabolic process; protein heterotetramerization; protein localization to postsynaptic membrane; protein-containing complex assembly; regulation of axonogenesis; regulation of cell communication; regulation of dendrite morphogenesis; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of monoatomic cation transmembrane transport; regulation of neuron apoptotic process; regulation of neuronal synaptic plasticity; regulation of presynaptic membrane potential; regulation of respiratory gaseous exchange; regulation of synapse assembly; regulation of synaptic plasticity; response to amine; response to amphetamine; response to calcium ion; response to ethanol; response to fungicide; response to glycine; response to morphine; response to organic cyclic compound; rhythmic process; sensory perception of pain; social behavior; startle response; suckling behavior; synaptic transmission, glutamatergic; transcription by RNA polymerase II; visual learning
Reference #:  P35439 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; Grin1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; Nmdar1; NMDZ1; NR1
Gene Symbols: Grin1
Molecular weight: 105,509 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene