HMGN1 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. Belongs to the HMGN family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 16 C4|16 56.83 cM
Cellular Component:  chromatin; cytoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; nucleosomal DNA binding; protein binding
Biological Process:  chromatin organization; positive regulation of NAD+ ADP-ribosyltransferase activity; post-embryonic camera-type eye morphogenesis; pyrimidine dimer repair by nucleotide-excision repair; regulation of development, heterochronic; regulation of epithelial cell proliferation; regulation of transcription by RNA polymerase II; response to UV-B; response to UV-C; transcription-coupled nucleotide-excision repair
Reference #:  P18608 (UniProtKB)
Alt. Names/Synonyms: high mobility group nucleosomal binding domain 1; High mobility group nucleosome-binding domain-containing protein 1; high mobility group protein 14; high-mobility group nucleosome-binding domain-containing protein 1; Hmg-14; Hmg14; Hmgn1; MGC103397; Non-histone chromosomal protein HMG-14; OTTMUSP00000021569
Gene Symbols: Hmgn1
Molecular weight: 10,152 Da
Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs
Select Structure to View Below

HMGN1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene