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STYXL1
Catalytically inactive phosphatase. By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules. Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149'. Inhibits PTPMT1 phosphatase activity. By inhibiting PTPMT1, positively regulates intrinsic apoptosis. May play a role in the formation of neurites during neuronal development. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
protein binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein tyrosine/serine/threonine phosphatase activity; pseudophosphatase activity
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Biological Process:
intracellular signal transduction; negative regulation of phosphoprotein phosphatase activity; negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; protein dephosphorylation; regulation of intrinsic apoptotic signaling pathway
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Reference #:
Q9Y6J8
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 24 (putative); Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; DUSP24; Inactive dual specificity protein phosphatase MK-STYX; Map kinase phosphatase-like protein MK-STYX; MK-STYX; MKSTYX; serine/threonine/tyrosine interacting like 1; serine/threonine/tyrosine interacting-like 1; Serine/threonine/tyrosine-interacting-like protein 1; STYL1; STYXL1
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Gene Symbols: STYXL1
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Molecular weight:
35,818 Da
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Basal Isoelectric point:
5.73
Predict pI for various phosphorylation states
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