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RTN4IP1
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Mitochondrial |
| Chromosomal Location of human Ortholog: 6q21 |
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Cellular Component:
mitochondrial outer membrane; mitochondrion
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Molecular Function:
oxidoreductase activity; protein binding; zinc ion binding
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Biological Process:
nervous system development; regulation of dendrite development
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Disease: Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures
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Reference #:
Q8WWV3
(UniProtKB)
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Alt. Names/Synonyms: MGC12934; NIMP; NOGO-interacting mitochondrial protein; OPA10; reticulon 4 interacting protein 1; Reticulon-4-interacting protein 1, mitochondrial; RT4I1; RTN4IP1
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Gene Symbols: RTN4IP1
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Molecular weight:
43,590 Da
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Basal Isoelectric point:
9.22
Predict pI for various phosphorylation states
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