HPCA Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. Belongs to the recoverin family. Brain specific. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component:  axon; cytoplasm; cytosol; dendrite cytoplasm; dendrite membrane; dendritic spine head; extrinsic component of membrane; glutamatergic synapse; neuronal cell body membrane; perikaryon
Molecular Function:  actin binding; calcium ion binding; identical protein binding; kinase binding
Biological Process:  activation of phospholipase D activity; brain development; calcium-mediated signaling; cellular response to calcium ion; cellular response to electrical stimulus; cellular response to monosodium glutamate; inner ear development; negative regulation of guanylate cyclase activity; positive regulation of adenylate cyclase activity; positive regulation of protein targeting to membrane; regulation of postsynaptic neurotransmitter receptor internalization; regulation of voltage-gated calcium channel activity; response to Aroclor 1254; response to ketamine; response to L-glutamate; retina development in camera-type eye
Disease: Dystonia 2, Torsion, Autosomal Recessive
Reference #:  P84074 (UniProtKB)
Alt. Names/Synonyms: BDR2; Calcium-binding protein BDR-2; dystonia 2, torsion (autosomal recessive); DYT2; hippocalcin; HPCA; neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin
Gene Symbols: HPCA
Molecular weight: 22,427 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene