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OXCT2
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Belongs to the 3-oxoacid CoA-transferase family. Testis specific. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.8.3.5; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Transferase |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
mitochondrial matrix; mitochondrion; motile cilium
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Molecular Function:
succinyl-CoA:3-oxo-acid CoA-transferase activity
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Biological Process:
cellular ketone body metabolic process; ketone body catabolic process
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Reference #:
Q9BYC2
(UniProtKB)
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Alt. Names/Synonyms: 3-oxoacid CoA transferase 2; 3-oxoacid CoA-transferase 2; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; FKSG25; FLJ00030; OXCT2; SCOT-t; SCOT2; SCOTT; Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial; testis-specific succinyl CoA:3-oxoacid CoA-transferase; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase
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Gene Symbols: OXCT2
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Molecular weight:
56,140 Da
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Basal Isoelectric point:
6.73
Predict pI for various phosphorylation states
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