Mad1
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription, coactivator/corepressor |
Chromosomal Location of mouse Ortholog: 6 D1|6 37.75 cM |
Cellular Component:
chromatin; cytosol; Mad-Max complex; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Reference #:
P50538
(UniProtKB)
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Alt. Names/Synonyms: AW122478; Mad; Mad1; Max dimerization protein 1; Max dimerizer 1; Mxd1; Protein MAD
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Gene Symbols: Mxd1
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Molecular weight:
25,562 Da
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Basal Isoelectric point:
7.11
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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