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HRASLS2
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity. Belongs to the H-rev107 family. Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.1.-; EC 3.1.1.- |
| Chromosomal Location of human Ortholog: 11q12.3 |
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Cellular Component:
cytoplasm; cytosol; membrane
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Molecular Function:
1-acyl-2-lysophosphatidylserine acylhydrolase activity; acyltransferase activity; N-acyltransferase activity; phosphatidylserine 1-acylhydrolase activity; phospholipase A1 activity; phospholipase A2 activity; protein binding
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Biological Process:
lipid catabolic process; localization; N-acylphosphatidylethanolamine metabolic process; phosphatidylethanolamine acyl-chain remodeling
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Reference #:
Q9NWW9
(UniProtKB)
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Alt. Names/Synonyms: FLJ20556; HRAS like suppressor 2; HRAS-like suppressor 2; HRASLS2; HRSL2; Phospholipase A and acyltransferase 2; phospholipase A/acyltransferase-2; PLA1/2-2; PLAAT-2; PLAAT2; PLAT2
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Gene Symbols: PLAAT2
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Molecular weight:
17,394 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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