Mad1 Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component:  cytosol; mitochondrion; nuclear chromatin; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription corepressor activity
Biological Process:  negative regulation of transcription by RNA polymerase II
Reference #:  Q05195 (UniProtKB)
Alt. Names/Synonyms: antagonizer of myc transcriptional activity; BHLHC58; MAD; MAD protein (MAX-binding protein); MAD1; Max dimerization protein 1; Max dimerizer 1; MAX-binding protein; MGC104659; MXD1; Protein MAD
Gene Symbols: MXD1
Molecular weight: 25,254 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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