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GLUD2
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Expressed in retina, testis and, at a lower level, brain. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase |
| Chromosomal Location of human Ortholog: Xq24 |
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Cellular Component:
cytosol; mitochondrial matrix; mitochondrion
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Molecular Function:
ADP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase (NADP+) activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; leucine binding
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Biological Process:
glutamate biosynthetic process; glutamate catabolic process; glutamate metabolic process
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Disease: Parkinson Disease, Late-onset
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Reference #:
P49448
(UniProtKB)
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Alt. Names/Synonyms: DHE4; GDH 2; GDH2; GLUD2; GLUDP1; glutamate dehydrogenase 2; Glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; testicular secretory protein Li 14
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Gene Symbols: GLUD2
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Molecular weight:
61,434 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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