GLUD2 Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Expressed in retina, testis and, at a lower level, brain. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase
Chromosomal Location of human Ortholog: Xq24
Cellular Component:  cytosol; mitochondrial matrix; mitochondrion
Molecular Function:  ADP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase (NADP+) activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; leucine binding
Biological Process:  glutamate biosynthetic process; glutamate catabolic process; glutamate metabolic process
Disease: Parkinson Disease, Late-onset
Reference #:  P49448 (UniProtKB)
Alt. Names/Synonyms: DHE4; GDH 2; GDH2; GLUD2; GLUDP1; glutamate dehydrogenase 2; Glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; testicular secretory protein Li 14
Gene Symbols: GLUD2
Molecular weight: 61,434 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene