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HAS3
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Belongs to the NodC/HAS family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase |
| Chromosomal Location of mouse Ortholog: 8 D3|8 53.28 cM |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; Golgi apparatus; hyaluranon cable; membrane; nucleus; plasma membrane
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Molecular Function:
glycosyltransferase activity; hyaluronan synthase activity; identical protein binding; transferase activity
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Biological Process:
extracellular matrix assembly; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of hyaluranon cable assembly
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Reference #:
O08650
(UniProtKB)
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Alt. Names/Synonyms: HA synthase 3; Has3; Hyaluronan synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3; HYAS3
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Gene Symbols: Has3
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Molecular weight:
63,349 Da
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Basal Isoelectric point:
8.94
Predict pI for various phosphorylation states
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