ENOX2
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell surface; Cytoskeletal; EC 1.-.-.-; Oxidoreductase |
Chromosomal Location of human Ortholog: Xq26.1 |
Cellular Component:
cytosol; external side of plasma membrane; extracellular space; plasma membrane
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Molecular Function:
oxidoreductase activity; RNA binding
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Biological Process:
electron transport chain; ultradian rhythm
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Reference #:
Q16206
(UniProtKB)
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Alt. Names/Synonyms: APK1; APK1 antigen; COVA1; Cytosolic ovarian carcinoma antigen 1; ecto-NADPH oxidase disulfide-thiol exchanger 2; Ecto-NOX disulfide-thiol exchanger 2; ENOX2; Hydroquinone [NADH] oxidase; Protein disulfide-thiol oxidoreductase; tNOX; Tumor-associated hydroquinone oxidase; tumor-associated NADH oxidase
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Gene Symbols: ENOX2
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Molecular weight:
70,082 Da
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Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
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