EYA2
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. Belongs to the HAD-like hydrolase superfamily. EYA family. Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Apoptosis; Cell development/differentiation; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) |
Chromosomal Location of human Ortholog: 20q13.12 |
Cellular Component:
cytosol; mitochondrion; nucleoplasm; nucleus
|
Molecular Function:
histone H2AXY142 phosphatase activity; magnesium ion binding; protein binding; protein tyrosine phosphatase activity
|
Biological Process:
anatomical structure development; cell differentiation; chromatin remodeling; DNA repair; extrinsic apoptotic signaling pathway in absence of ligand; mesodermal cell fate specification; mitochondrial outer membrane permeabilization; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of DNA repair; protein dephosphorylation; striated muscle tissue development
|
Reference #:
O00167
(UniProtKB)
|
Alt. Names/Synonyms: EAB1; EYA transcriptional coactivator and phosphatase 2; EYA2; Eyes absent homolog 2; eyes absent homolog 2 (Drosophila); MGC10614
|
Gene Symbols: EYA2
|
Molecular weight:
59,232 Da
|
Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
|