EFNA1 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Belongs to the ephrin family. Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor; Tumor suppressor
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  extracellular region; plasma membrane
Molecular Function:  ephrin receptor binding; protein binding; signaling receptor binding
Biological Process:  angiogenesis; aortic valve morphogenesis; cell migration; cell-cell signaling; endocardial cushion to mesenchymal transition involved in heart valve formation; ephrin receptor signaling pathway; mitral valve morphogenesis; negative regulation of dendritic spine morphogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of MAPK cascade; negative regulation of proteolysis involved in cellular protein catabolic process; negative regulation of thymocyte apoptotic process; negative regulation of transcription by RNA polymerase II; notochord formation; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of protein tyrosine kinase activity; protein stabilization; regulation of angiogenesis; regulation of axonogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading
Reference #:  P20827 (UniProtKB)
Alt. Names/Synonyms: B61; ECKLG; EFL1; EFNA1; EPH-related receptor tyrosine kinase ligand 1; ephrin A1; Ephrin-A1; Ephrin-A1, secreted form; epididymis secretory sperm binding protein; EPLG1; gastric cancer metastasis associated long noncoding RNA; GMAN; Immediate early response protein B61; LERK-1; LERK1; ligand of eph-related kinase 1; TNF alpha-induced protein 4; TNFAIP4; Tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4
Gene Symbols: EFNA1
Molecular weight: 23,787 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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