ENTPD2 In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP Belongs to the GDA1/CD39 NTPase family. Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.6.1.-; Extracellular matrix; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine

Chromosomal Location of human Ortholog: 9q34.3

Cellular Component: basement membrane; endoplasmic reticulum membrane; membrane; plasma membrane

Molecular Function: ATP binding; GDP phosphatase activity; nucleoside diphosphate phosphatase activity; protein binding; ribonucleoside triphosphate phosphatase activity; UDP phosphatase activity

Biological Process: G protein-coupled receptor signaling pathway; nucleoside diphosphate catabolic process; platelet activation; purine ribonucleoside diphosphate catabolic process

Reference #: Q9Y5L3 (UniProtKB)

Alt. Names/Synonyms: CD39 antigen-like 1; CD39-like-1; CD39L1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPase 2; Ecto-ATPDase 2; Ectonucleoside triphosphate diphosphohydrolase 2; ENTP2; ENTPD2; NTPDase 2; NTPDase-2

Gene Symbols: ENTPD2

Molecular weight: 53,665 Da

Basal Isoelectric point: 8.58 Predict pI for various phosphorylation states

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ENTPD2

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