ENTPD2 In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP Belongs to the GDA1/CD39 NTPase family. Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; Extracellular matrix; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  basement membrane; endoplasmic reticulum membrane; membrane; plasma membrane
Molecular Function:  ATP binding; GDP phosphatase activity; nucleoside diphosphate phosphatase activity; protein binding; ribonucleoside triphosphate phosphatase activity; UDP phosphatase activity
Biological Process:  G protein-coupled receptor signaling pathway; nucleoside diphosphate catabolic process; platelet activation; purine ribonucleoside diphosphate catabolic process
Reference #:  Q9Y5L3 (UniProtKB)
Alt. Names/Synonyms: CD39 antigen-like 1; CD39-like-1; CD39L1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPase 2; Ecto-ATPDase 2; Ectonucleoside triphosphate diphosphohydrolase 2; ENTP2; ENTPD2; NTPDase 2; NTPDase-2
Gene Symbols: ENTPD2
Molecular weight: 53,665 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene