RAB21 Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Belongs to the small GTPase superfamily. Rab family. Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q21.1
Cellular Component:  axon cytoplasm; cleavage furrow; cytoplasmic side of early endosome membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle membrane; cytosol; early endosome membrane; endoplasmic reticulum membrane; endosome; Golgi cisterna membrane; synapse; trans-Golgi network; vesicle membrane
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding
Biological Process:  anterograde axonal transport; positive regulation of dendrite morphogenesis; positive regulation of early endosome to late endosome transport; positive regulation of receptor-mediated endocytosis; regulation of axon extension; regulation of exocytosis
Reference #:  Q9UL25 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAB21; KIAA0118; RAB21; RAB21, member RAS oncogene family; Ras-related protein Rab-21
Gene Symbols: RAB21
Molecular weight: 24,348 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene