RNF5 Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; integral component of membrane; mitochondrial membrane
Molecular Function:  identical protein binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  cellular protein catabolic process; endoplasmic reticulum mannose trimming; ER-associated misfolded protein catabolic process; ERAD pathway; negative regulation of autophagy; protein destabilization; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of autophagosome assembly; response to bacterium; transmembrane transport; ubiquitin-dependent ERAD pathway
Reference #:  Q99942 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF5; G16; HsRma1; NG2; Protein G16; Ram1 homolog; RING finger protein 5; ring finger protein 5, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF5; RING5; RMA1; RNF5
Gene Symbols: RNF5
Molecular weight: 19,881 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene