galectin-8
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion |
Chromosomal Location of human Ortholog: 1q43 |
Cellular Component:
cytoplasm; cytoplasmic vesicle; cytosol; extracellular space
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Molecular Function:
carbohydrate binding; integrin binding; protein binding
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Biological Process:
cellular response to virus; lymphatic endothelial cell migration; xenophagy
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Reference #:
O00214
(UniProtKB)
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Alt. Names/Synonyms: Gal-8; galectin 8; Galectin-8; galectin-8g; lectin, galactoside-binding, soluble, 8; LEG8; LGALS8; PCTA-1; PCTA1; Po66 carbohydrate binding protein; Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1
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Gene Symbols: LGALS8
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Molecular weight:
35,808 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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