galectin-8 Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell adhesion

Chromosomal Location of human Ortholog: 1q43

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extracellular space

Molecular Function: carbohydrate binding; integrin binding; protein binding

Biological Process: cellular response to virus; lymphatic endothelial cell migration; xenophagy

Reference #: O00214 (UniProtKB)

Alt. Names/Synonyms: Gal-8; galectin 8; Galectin-8; galectin-8g; lectin, galactoside-binding, soluble, 8; LEG8; LGALS8; PCTA-1; PCTA1; Po66 carbohydrate binding protein; Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1

Gene Symbols: LGALS8

Molecular weight: 35,808 Da

Basal Isoelectric point: 8.33 Predict pI for various phosphorylation states

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galectin-8

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