| GABRA1 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Functions also as histamine receptor and mediates cellular responses to histamine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily. Note: This description may include information from UniProtKB. |
| Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 5q34 |
| Cellular Component: chloride channel complex; cytoplasmic vesicle membrane; dendrite membrane; GABA receptor complex; GABA-A receptor complex; GABA-ergic synapse; neuron projection; plasma membrane; postsynapse; postsynaptic membrane; synapse |
| Molecular Function: benzodiazepine receptor activity; chloride channel activity; GABA receptor activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated monoatomic ion channel activity; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| Biological Process: chloride transmembrane transport; gamma-aminobutyric acid signaling pathway; inhibitory synapse assembly; nervous system process; regulation of postsynaptic membrane potential; signal transduction; synaptic transmission, GABAergic |
| Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 13; Epileptic Encephalopathy, Early Infantile, 19 |
| Reference #: P14867 (UniProtKB) |
| Alt. Names/Synonyms: ECA4; EIEE19; EJM; EJM5; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid type A receptor alpha1 subunit; gamma-aminobutyric acid type A receptor subunit alpha1; GBRA1 |
| Gene Symbols: GABRA1 |
| Molecular weight: 51,802 Da |
| Basal Isoelectric point: 9.27 Predict pI for various phosphorylation states |
| CST Pathways: PI3K/Akt Signaling |
| Select Structure to View Below |
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GABRA1 |
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Cross-references to other databases:
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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