FRZB Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Belongs to the secreted frizzled-related protein (sFRP) family. Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component:  extracellular space; membrane
Molecular Function:  Wnt-protein binding
Biological Process:  cochlea morphogenesis; convergent extension involved in organogenesis; negative regulation of canonical Wnt signaling pathway; negative regulation of cartilage development; negative regulation of cell development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of hepatocyte differentiation; negative regulation of Wnt signaling pathway; neural crest cell differentiation; positive regulation of apoptotic process; positive regulation of fat cell differentiation; skeletal system development; somite development
Disease: Osteoarthritis Susceptibility 1
Reference #:  Q92765 (UniProtKB)
Alt. Names/Synonyms: FIZ; FRE; Frezzled; Fritz; frizzled homolog-related; frizzled related protein; frizzled-related protein; Frizzled-related protein 1; FRP; FRP-3; FRZB; FrzB-1; FRZB-PEN; FRZB1; FZRB; hFIZ; OS1; Secreted frizzled-related protein 3; sFRP-3; SFRP3; SRFP3
Gene Symbols: FRZB
Molecular weight: 36,254 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene