SLC27A1 Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Belongs to the ATP-dependent AMP-binding enzyme family. Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.2.1.-; Ligase; Lipid-binding; Membrane protein, integral; Mitochondrial; Vesicle
Chromosomal Location of human Ortholog: 19p13.11
Cellular Component:  basal plasma membrane; endoplasmic reticulum; mitochondrial inner membrane; plasma membrane
Molecular Function:  arachidonate-CoA ligase activity; biotin transmembrane transporter activity; efflux transmembrane transporter activity; fatty acid transmembrane transporter activity; identical protein binding; long-chain fatty acid transporter activity; long-chain fatty acid-CoA ligase activity; nucleotide binding; oleate transmembrane transporter activity; oleoyl-CoA ligase activity; protein binding; very long-chain fatty acid-CoA ligase activity
Biological Process:  adiponectin-activated signaling pathway; biotin import across plasma membrane; biotin transport; cardiolipin biosynthetic process; export across plasma membrane; glucose import in response to insulin stimulus; lipid transport across blood-brain barrier; long-chain fatty acid import across plasma membrane; long-chain fatty acid import into cell; long-chain fatty acid metabolic process; long-chain fatty acid transport; medium-chain fatty acid transport; negative regulation of phospholipid biosynthetic process; phosphatidic acid biosynthetic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylglycerol biosynthetic process; phosphatidylinositol biosynthetic process; phosphatidylserine biosynthetic process; positive regulation of heat generation; positive regulation of protein serine/threonine kinase activity; positive regulation of triglyceride biosynthetic process; response to cold; response to insulin; transport across blood-brain barrier
Reference #:  Q6PCB7 (UniProtKB)
Alt. Names/Synonyms: ACSVL5; FATP; FATP-1; FATP1; Fatty acid transport protein 1; FLJ00336; Long-chain fatty acid transport protein 1; MGC71751; S27A1; SLC27A1; solute carrier family 27 (fatty acid transporter), member 1; Solute carrier family 27 member 1
Gene Symbols: SLC27A1
Molecular weight: 71,108 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene