MPP2 Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells. Belongs to the MAGUK family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  cytoplasm; cytoskeleton; dendrite membrane; dendritic shaft; dendritic spine; dendritic spine membrane; postsynaptic density
Molecular Function:  protein binding
Biological Process:  excitatory postsynaptic potential; long-term synaptic potentiation; protein homooligomerization
Reference #:  Q14168 (UniProtKB)
Alt. Names/Synonyms: Discs large homolog 2; discs large, homolog 2; DKFZp686A06252; DKFZp686J2189; DKFZp761D0712; DLG2; MAGUK p55 subfamily member 2; membrane palmitoylated protein 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2); MPP2; palmitoylated membrane protein 2; Protein MPP2
Gene Symbols: MPP2
Molecular weight: 64,581 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
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MPP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene